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US 12,569,499 B2Granted
Intravenous formulations of RK-33
AssigneeNatsar Pharmaceuticals, Inc.
InventorVenu Raman
Life of this patent
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Abstract
The present disclosure provides a liquid formulation comprising: (a) RK-33, (b) cholic acid or derivative thereof, (c) a water-soluble polyvinyl polymer, and (d) water. The disclosure also provides a method of making a liquid formulation comprising RK-33. The disclosure further provides a method of treating cancer in a subject in need thereof, the method comprising (a) diluting the formulation of the present disclosure to form a diluted formulation, and (b) intravenously administering to the subject the diluted formulation.
Claims19
A liquid formulation comprising,
- a. RK-33 as represented by Formula I
- b. cholic acid or derivative thereof,
- c. a water-soluble polyvinyl polymer, and
- d. water,
- wherein the RK-33 does not precipitate or significantly aggregate.
2 more elements
A liquid formulation comprising,
- a. about 10% to about 25% (wt/wt) RK-33;
- b. about 0.1% to about 1.0% (wt/wt) sodium deoxycholate;
- c. about 1% to about 10% PVP;
- and
- e. water,
- wherein the RK-33 does not precipitate or significantly aggregate.
3 more elements
Dependencies are inferred from the claim text.