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US 12,569,491 B2Granted
Methods for treating testicular and ovarian adrenal rest tumors
AssigneeSpruce Biosciences, Inc.
InventorsAlexis Howerton, Hal Gerber
Life of this patent
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Abstract
Provided herein are compounds and pharmaceutical compositions for the prevention and treatment of testicular adrenal rest tumors (TART) or ovarian adrenal rest tumors (OART).
Claims19
A method of treating an endocrine disorder associated with corticotropin-releasing factor type-1 (CRF1) activity, comprising administering to a subject in need thereof a small molecule CRF1 antagonist, or a pharmaceutically acceptable salt thereof, wherein the small molecule CRF1 antagonist is:
- or a pharmaceutically acceptable salt thereof,
- wherein the small molecule CRF1 antagonist is administered to the subject twice per day, and
- wherein the subject is in the fed state,
- wherein the endocrine disorder associated with CRF1 activity is a testicular adrenal rest tumor (TART) or an ovarian adrenal rest tumor (OART).
1 more element
Dependencies are inferred from the claim text.