Method for activating follicles by means of using small-molecule compound, and preparation thereof
AssigneesTsingtao A-Smart Medical Technology Co., Ltd., Shandong University
InventorsJinlong Ma, Hongbin Liu, Lianbao Cao, Keliang Wu, Xianwei Su, Gang Lu
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Abstract
Disclosed are a method and culture medium for performing an in vivo treatment on ovaries of mammals including humans or performing in vitro culturing on ex vivo ovaries or ovarian tissue by means of using 4-vinylcyclohexene diepoxide. The method or culture medium provided facilitates the retention and enhancement of the developmental and reproductive potential of mammalian ovaries or ovarian tissue, and is particularly capable of promoting follicle maturation and increasing the number of ovulations.
Claims5
An in vitro culture method of ovary or ovarian tissue of a mammal, said method comprising adding 4-vinylcyclohexene diepoxide or its analog in a culture medium, wherein the 4-vinylcyclohexene diepoxide is about 1.0 nM-20 nM in the culture medium.
Dependencies are inferred from the claim text.