Bio-inspired tissue-adhesive hydrogel patch and uses thereof
AssigneeCellartgen Inc.
InventorsSeung Woo Cho, Ji Soo Shin, Soo Jeong Choi, Dong Hoon Choi
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Abstract
The present disclosure relates to a catechol group- or pyrogallol group-functionalized biocompatible polymer hydrogel patch having excellent biocompatibility and tissue adhesion, and uses for drug delivery, cell transplantation and tissue regeneration using the same. The biocompatible polymer hydrogel patch functionalized with the catechol group or pyrogallol group of the present disclosure has remarkably excellent mechanical properties and tissue adhesion compared with a solution-based bulk hydrogel. Therefore, it can load cells and a drug in vivo for a long time and also safely and efficiently deliver the cells and the drug to a target site.
Claims11
A drug or cell delivery system comprising a biocompatible polymer functionalized with a catechol group,
- wherein the drug or cell delivery system is manufactured by:
- (a) preparing a hydrogel patch by freeze-drying a solution of the biocompatible polymer functionalized with the catechol group;
- (b) contacting the hydrogel patch prepared in the (a) with a drug or cells;
- and
- (c) contacting an oxidizing agent after the (b),
- wherein the biocompatible polymer is hyaluronic acid, and
- wherein the hydrogel patch is a thin film and can be cut into a desired shape for use as the drug or cell delivery system.
A method of manufacturing a drug or cell delivery system, comprising:
- (a) preparing a hydrogel patch by freeze-drying a solution of a biocompatible polymer functionalized with a catechol group;
- and
- (b) contacting the hydrogel patch prepared in the (a) with the drug or cells;
- and
- (c) contacting an oxidizing agent after the (b),
- wherein the biocompatible polymer is hyaluronic acid, and
- wherein the hydrogel patch is a thin film and can be cut into a desired shape for use as the drug or cell delivery system.
A method of forming a structure inspired by a biological tissue, comprising:
- (a) wrapping a mold of a predetermined shape with a hydrogel patch prepared by freeze-drying a solution of a biocompatible polymer functionalized with a catechol group;
- and
- (b) contacting stem cells with the hydrogel patch;
- and
- (c) contacting an oxidizing agent after applying the cells to the hydrogel patch,
- wherein the biocompatible polymer is hyaluronic acid, and
- wherein the hydrogel patch is a thin film and can be cut into a desired shape for use in forming a structure inspired by a biological tissue.
Dependencies are inferred from the claim text.