Enteral sustained-release sugar alcohol additive and preparation method and application thereof

A method of preparing an enteral sustained-release sugar alcohol additive, wherein:

• the enteral sustained-release sugar alcohol additive includes an inner layer structure and an outer layer structure;
• wherein the inner layer structure contains xylitol and agar;
• wherein the outer layer structure contains:
• (i) carrageenan, gellan gum, xanthan gum, or guar gum;
• (ii) vitamin B12 and L-arabinose;
• and
• (iii) fermented Bifidobacterium, Propionibacterium, or Lactobacillus;
• wherein in the enteral sustained-release sugar alcohol additive, a component ratio of the xylitol to the L-arabinose to the vitamin B12 is (1-33):1:0.005;
• wherein the method of preparing comprises the following steps:
• 1) mixing and sterilizing the xylitol and the agar, placing the mixture into a ball mould, and standing the mixture for cooling so as to prepare xylitol agar pellets, a concentration of the agar being 2%;
• 2) preparing a solution of carrageenan, gellan gum, xanthan gum, or guar gum, adding the vitamin B12 and the L-arabinose to the solution, and mixing to uniformity so as to obtain a mixed solution, and then wrapping the xylitol agar pellets prepared in step 1 with the mixed solution to obtain xylitol agar two-layer colloidal pellets wrapped with the mixed solution;
• and
• 3) placing the two-layer colloidal pellets prepared in step 2 into a fermentation medium containing Bifidobacterium, Propionibacterium, or Lactobacillus and culturing, and then taking out the two-layer colloidal pellets and freeze drying or hot air drying to obtain the enteral sustained-release sugar alcohol additive.