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AssigneeAPeT Holding B.V.
InventorsHendrik Jan Cornelis Meijerink, Lekhram Changoer, Willem Blom, Marinella Regina Visser, Henderik Willem Frijlink, Anko Cornelus Eissens
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The invention relates to floating drug delivery systems (FDDS) that provide solutions to the particular problems often encountered with floating drug delivery systems described in the art. On such generally recognized problem is the vulnerability of the systems, especially damage to the gas-filled compartment making it accessible to water so as to impair its buoyancy, ultimately resulting in insufficient gastric residence time. The invention, in an aspect, provides a self-repairing FDDS that maintains its floating capacity after damaging. The floating drug delivery systems of the invention, furthermore, allow for incorporation of high loads of active ingredients. The floating drug delivery systems can be designed in such a way that release of active ingredient from the system occurs entirely independent from the pH of the fluid surrounding the system. Furthermore, the procedure of manufacturing the floating drug delivery system of the invention is simple and straightforward, and therefore economically attractive.
A floating drug delivery system (FDDS), consisting of (i) a particle having a hollow, gas-filled core bordered by a wall of a polymer selected from the group of aqueous soluble or degradable polymers, and (ii) one or more coating layers surrounding said wall, said one or more coating lavers each comprising an active ingredient and a coating material, wherein at least 75 wt. % of the coating material is a combination of hydroxypropyl methylcellulose (HPMC) and starch.
Dependencies are inferred from the claim text.