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US 12,569,422 B2Granted
Composition and method of inhibiting cortisone reductase by applying it to the skin
AssigneeAmorepacific Corporation
InventorsEun Jeong Choi, Young Gyu Kang, Jihyun Kim, Euidong Son, Gayoung Cho, Sowoong Choi, Hyoung June Kim, Tae Ryong Lee
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Abstract
Provided are a composition including coumestrol extracted from soybeans as an active ingredient, and a method of inhibiting cortisone reductase by applying it to skin of a subject.
Claims2
A method of improving skin barrier function that has been compromised by an increase in the cortisol level within the epidermis in a subject, comprising applying an effective amount of a composition to skin of the subject,
- wherein the composition comprises coumestrol extracted from soybeans as an active ingredient in a concentration range of 0.001 μM to 10 μM,
- wherein the increase in cortisol level within the epidermis is caused by mental stress,
- wherein the increase in cortisol level within the epidermis caused by mental stress is simulated by UV irradiation and the addition of cortisone to human keratinocytes, and
- wherein the composition is a cosmetic composition.
1 more element
Dependencies are inferred from the claim text.