Methods, systems, and materials for making unit dosage forms

A method for bulk manufacture of unit dosage forms, the method comprising:

• rotating a drum around a rotational axis at a rotational speed, the drum having an outer surface with a plurality of cavities formed thereon:
• chilling the outer surface of the drum to a target temperature:
• dispensing a liquid formulation comprising a therapeutic or biotherapeutic agent into one or more of the plurality of cavities while rotating the drum about its rotational axis;
• freezing the liquid formulation within the one or more of the plurality of cavities to form a frozen unit in each of the one or more of the plurality of cavities;
• collecting the frozen units from the one or more of the plurality of cavities;
• and
• drying the collected frozen units to form the unit dosage forms.