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US 12,569,229 B2Granted
Capturing truncated proteoforms in exhaled breath for diagnosis and treatment of diseases
AssigneeZeteo Tech, Inc.
InventorsDapeng Chen, Wayne A. Bryden, Michael McLoughlin
Life of this patent
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Abstract
Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.
Claims17
An exhaled breath collection system for diagnosis and treatment of a disease, the system comprising:
- one or more sample capture elements comprising a packed bed column in each to selectively capture aerosolized truncated proteoforms characteristic of the disease and present in the exhaled breath produced by a patient;
- and
- a subsystem comprising one or more of a pump configured to draw the aerosolized truncated proteoforms in the exhaled breath into the one or more sample capture elements, a power supply, or a controller, wherein the subsystem is disposed in fluid communication with the one or more sample capture elements, and is configured to control the operation of the one or more sample capture elements.
Dependencies are inferred from the claim text.