US 12,566,228 B2Granted

Temperature cycling method for hyperpolarization of target molecules and contrast agents using parahydrogen

AssigneesNorth Carolina State University, Wayne State University, Board of Trustees of Southern Illinois University, National Institutes of Health Nhlbi

InventorsThomas Theis, Mustapha Abdulmojeed, Sören Lehmkuhl, Patrick TomHon, Iuliia Mandzhieva, Eduard Y. Chekmenev, Isaiah Adelabu, Mohammad Kabir, Shiraz Nantogma, Jessica Ettedgui, Rolf Eric Swenson, Boyd Goodson

Life of this patent

Estimating the term…

patentgrep

Loading patent…

Abstract

Hyperpolarized target molecules and contrast agents comprising the same, methods of making the same, and methods of imaging using same are provided. In a further aspect, imaging performed using the hyperpolarized target molecules and contrast agent can enable real time monitoring and diagnosis of diseases including various cancers and metabolic disorders. The methods are cryogen-free and inexpensive and can be performed in a short time.

Claims20

Dependent claims

A method for hyperpolarization of a target molecule, the method comprising:

(a) transitioning a composition comprising the target molecule and a polarization transfer catalyst between a first state and a second state;
and
(b) contacting the composition with parahydrogen;
wherein, in the first state, hydrogen exchange rates for the target molecule are from about 1 Hz to about 100 Hz and substrate exchange is minimized or eliminated;
wherein, in the second state, rates of substrate exchange are up to about 100 Hz, and hydrogen exchange rates for the target molecule are comparable to rates of substrate exchange, and
wherein the first state represents a low temperature and the second state represents a high temperature.

3 more elements

Dependencies are inferred from the claim text.