Back to results
US 12,566,140 B2Granted
Biosensors based on optical probing and sensing
AssigneeGenalyte, Inc.
InventorsLawrence Cary Gunn, III, Muzammil Iqbal, Brad Spaugh, Frank Tybor
Life of this patent
Estimating the term…
Abstract
Apparatus, sensor chips and techniques for optical sensing of substances by using optical sensors on sensor chips.
Claims17
A biosensing system comprising:
- a light source configured to generate input light comprising a range of wavelengths;
- a beam splitter configured to divide the input light into a first portion and a second portion;
- a resonant optical biosensor configured to receive the first portion of the input light and to output a first transmission spectrum of light that comprises a resonance within the range of wavelengths, the resonance corresponding to a wavelength that depends on the presence of an analyte at the resonant optical biosensor;
- a first detector configured to detect the first transmission spectrum output from the resonant optical biosensor;
- a wavelength referencing device configured to receive the second portion of the input light and to output a second transmission spectrum of light that comprises plurality of resonances within the range of wavelengths;
- a second detector configured to detect the second transmission spectrum output from the wavelength referencing device;
- and
- a processor configured to:
- analyze the first and second transmission spectra and to determine the wavelength corresponding to the resonance of the first transmission spectrum of light output from the resonant optical biosensor based at least in part on the plurality of resonances in the second transmission spectrum output from the wavelength referencing device;
- identify a first resonance in the second transmission spectrum at a wavelength less than a wavelength of the resonance in the first transmission spectrum;
- identify a second resonance in the second transmission spectrum at a wavelength greater than that of the resonance in the first transmission spectrum;
- and
- determine the wavelength corresponding to the resonance of the first transmission spectrum of light output from the resonant optical biosensor, at least in part, by determining a position of the resonance of the first transmission spectrum with respect to the first and second resonances of the second transmission spectrum.
10 more elements
A method comprising:
- generating input light comprising a range of wavelengths;
- dividing the input light into a first portion and a second portion;
- providing the first portion of the input light to a resonant optical biosensor;
- receiving, in response to the provision of the first portion of the input light to the resonant optical biosensor, a first transmission spectrum of light that comprises a resonance within the range of wavelengths, the resonance corresponding to a wavelength that depends on the presence of an analyte at the resonant optical biosensor;
- detecting, with a first detector, the first transmission spectrum received from the resonant optical biosensor;
- providing the second portion of the input light to a wavelength referencing device;
- detecting, with a second detector, a second transmission spectrum of light that comprises a plurality of resonances within the range of wavelengths, wherein the second transmission spectrum is output from the wavelength referencing device in response to the provision of the second portion of the input light to the wavelength referencing device;
- analyzing the first and second transmission spectra and to determine a wavelength corresponding to the resonance of the first transmission spectrum based at least in part on the plurality of resonances in the second transmission spectrum output from the wavelength referencing device;
- identifying a first resonance in the second transmission spectrum at a wavelength less than a wavelength of the resonance in the first transmission spectrum;
- identifying a second resonance in the second transmission spectrum at a wavelength greater than that of the resonance in the first transmission spectrum;
- and
- determining the wavelength corresponding to the resonance of the first transmission spectrum of light output from the resonant optical biosensor, at least in part, by determining a position of the resonance of the first transmission spectrum with respect to the first and second resonances of the second transmission spectrum.
9 more elements
Dependencies are inferred from the claim text.