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US 12,566,124 B2Granted
Apparatus, systems and methods for in vitro screening of complex biological fluids
AssigneeThe Administrators of the Tulane Educational Fund
InventorsDamir Khismatullin, Nithya Kasireddy
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Abstract
The disclosed apparatus, systems and methods relate to technology that provides a method for the assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device via the application of a sweeping frequency to the levitating sample and the corresponding assessment of extracted sample parameters.
Claims14
A noncontact in vitro method of analyzing a sample, comprising:
- levitating the sample using an acoustic carrier signal at a first frequency;
- perturbing the sample using an acoustic modulation signal at one or more second frequencies;
- measuring the oscillations of the sample resulting from the acoustic modulation signal to obtain amplitude measurements against time;
- analyzing amplitude measurements against time to calculate an extracted parameter;
- and
- filtering the amplitude measurements with a bandpass filter,
- wherein one or more second frequencies is a single frequency.
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