Compositions and methods targeting the nucleotide free state of RAS to block oncogenic signaling and transformation
AssigneesMUSC Foundation for Research Development, New York University, The United States Government as represented by the Department of Veterans Affairs
InventorsJohn O'Bryan, Shohei Koide, Akiko Koide
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Abstract
The invention provides compositions and methods for binding Ras in a nucleotide free state (apo RAS) and inhibiting Ras signaling. In one embodiment, the invention provides monobodies that specifically bind apo RAS and methods of use. Thus, in diseases and conditions where a reduction of Ras signaling is beneficial, such inhibitory compositions act as therapeutics.
Claims6
A composition comprising at least one molecule comprising a monobody domain that selectively binds RAS in a nucleotide free state (apo RAS) but not RAS in the nucleotide-bound state, wherein the monobody domain comprises a sequence selected from the group consisting of SEQ ID NO:
- 1-6.
Dependencies are inferred from the claim text.