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US 12,565,535 B2Granted
Chimeric antigen receptors targeted to PSCA
AssigneeCity of Hope
InventorsSaul J. Priceman, Christine E. Brown, Stephen J. Forman
Life of this patent
Estimating the term…
Abstract
Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.
Claims19
A nucleic acid molecule encoding a chimeric antigen receptor (CAR) selected from the group consisting of:
- (a) a CAR comprising a Prostate Stem Cell Antigen (PSCA) scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 9, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21;
- (b) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 2, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21;
- or
- (c) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 10, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21.
16 more elements
A population of human T cells comprising a nucleic acid encoding a CAR selected from the group consisting of:
- (a) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 9, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21;
- (b) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 2, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21;
- or
- (c) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 10, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21.
16 more elements
A CAR selected from the group consisting of:
- (a) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 9, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21;
- (b) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 2, a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21;
- or
- (c) a CAR comprising a PSCA scFV comprising the amino acid sequence of SEQ ID NO:
- 38, a spacer comprising the amino acid sequence of SEQ ID NO:
- 10 a CD4 transmembrane domain comprising the amino acid sequence of SEQ ID NO:
- 16, a 41-BB co-stimulatory domain comprising the amino acid sequence of SEQ ID NO:
- 24, and CD3ζ domain comprising the amino acid sequence of SEQ ID NO:
- 21.
16 more elements
Dependencies are inferred from the claim text.