Carrier protein for improving properties of bioactive protein
AssigneeZhejiang Doer Biologics Corporation
InventorYanshan Huang
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Abstract
The present disclosure provides a carrier protein for improving properties of a bioactive protein. The carrier protein has a G-X-Y ternary repetitive structure, G is glycine, and X and Y are independently selected from proline, alanine and glutamic acid. The present disclosure further provides a fusion protein containing the carrier protein and the bioactive protein. The fusion protein of the present disclosure has improved biological properties, such as improved pharmacokinetic and physicochemical properties.
Claims14
A gelatin-like protein, wherein a core structure of the gelatin-like protein is U1-U2 or U1-U2- . . . Ua;
- wherein U1, U2, . . . , Ua are gelatin-like protein units, each of the gelatin-like protein units has an amino acid sequence selected from a group consisting of SEQ ID NO:
- 25, 27, 29, and 31;
- wherein a is an integer greater than or equal to 3;
- and the gelatin-like units are the same or different.
Dependencies are inferred from the claim text.