Inhibitors of influenza virus replication

A compound of Formula I:

• wherein:
• Y is O, S, SO2, or NR1;
• A and B are each independently null, C6-10aryl, or 5-7 membered heteroaryl having 1-3 ring heteroatoms selected from N, O, and S, and the aryl or heteroaryl is optionally substituted with 1-4 R2,
• L is a bond, NR3, or C(R4)2;
• RA is H, OH, —O—C6-10aryl, or —O—C1-6alkylene-O—CO2R4;
• RB is H, —OH, CO2R4, C(O)NH2, C(O)NHOH, C(O)NHOR5, C(O)NHR5, or CON(R5)2;
• each RC is independently H, OH, or CO2R4;
• R1 is H, C1-6alkyl, C1-6alkylene-C6-10aryl, or —CO2R4, and C6-10aryl is optionally substituted with OR4;
• each R2 is independently H, halo, —OH, C1-6 alkyl, C1-6alkoxy, —NH2, —NH(C1-6alkyl), —N(C1-6alkyl)2, —CN, —CO2R4, C6-10aryl, or 5-10 membered heterocyclyl having 1-3 ring heteroatoms selected from N, O, and S, and each of C1-6alkyl, C1-6alkoxy, C6-10aryl, and 5-10 membered heterocyclyl is optionally substituted with 1-3 halo;
• R3 is H, C1-6alkyl, —C(O) C1-6alkyl, or C1-6alkylene-C6-10aryl,
• each R4 is independently H, C1-6alkyl, or C0-6alkylene-Ar;
• each R5 is independently H, —OH, —C1-6 alkyl, C1-6alkoxy, —C1-6alkoxy-C6-10aryl, or —C0-6alkylene-C6-10aryl, and —C1-6 alkyl and C6-10aryl are optionally substituted with R6 or OR6;
• each R6 is independently H, —C1-6alkyl, —Co-6alkylene-C6-10aryl, —C1-6alkylene-O—C1-6alkyl, or
• and C1-6alkyl and C6-10aryl are optionally substituted with one or more R7;
• R7 is H, —OH, —CF3, or C6-10aryl;
• Ar is 5-10 membered heteroaryl comprising 1-3 ring heteroatoms selected from O, N, and S optionally substituted with (i) 1-3 C3-8 cycloalkyl or (ii) 5-10 membered heteroaryl comprising 1-3 ring heteroatoms selected from O, N, and S, and each of C3-8 cycloalkyl (i) and 5-10 membered heteroaryl (ii) is optionally substituted with 1-3 R2;
• x is 0 or 1;
• and
• z is 0 or 1,
• or a pharmaceutically acceptable salt thereof,
• with the proviso that when z is 0, then Y is NR1, A is null, and L is NR3, and
• with the proviso that when x is 0, L is NR3.