US 12,565,487 B2 · Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide

Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide

AssigneeBristol-Myers Squibb Company

InventorsKe Chen, Joerg Deerberg, Dong Lin, Michael Dummeldinger, Bahar Inankur, Sergei Kolotuchin, Jun Li, Amanda J. Rogers, Victor W. Rosso, Eric M. Simmons, Maxime C. D. Soumeillant, Daniel S. Treitler, Jianji Wang, Bin Zheng, Michael J. Smith, Neil A. Strotman, Steven Tymonko, Tamas Benkovics

Life of this patent

Estimating the term…

Abstract

The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

Claims5

Dependent claims

A compound selected from the following:

(a) one of the following five compounds:
(b) a salt of any one of the compounds in (a);
or
(c) a hydrate of any one of the compounds in (a), or a hydrate of a salt of any one of the compounds in (a).

1 more element

Dependencies are inferred from the claim text.

Facts

Application

18/134,564Filed 13 Apr 2023 · division

Priority

30 Mar 2017

Published

US 2023/0271946 A131 Aug 2023

Granted

3 Mar 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07D 403/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07B 59/00
Introduction of isotopes of elements into organic compounds
C07C 209/00
Preparation of compounds containing amino groups bound to a carbon skeleton
C07C 211/09
Of an acyclic saturated carbon skeleton: diamines

Family

Application62/478,789Us provisional application · filed 30 Mar 2017

PCT/US2018/025100Parent of this division · filed 29 Mar 2018

Application17/131,718Parent of this division · filed 22 Dec 2020

US 2023/0271946 A1Pre-grant publication · published 31 Aug 2023

US 11,649,226 B2Parent of this division

Application16/498,442Parent of this division

US 10,899,745 B2Parent of this division

US 2020/0109134 A1Published application

US 2021/0107897 A1Published application

US 12,565,487 B2This patent

From the US filing history. Foreign family members aren’t listed.