Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases
AssigneesBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Southern California
InventorsNicolas G. Bazan, Nicos A. Petasis
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Abstract
This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative diseases. Embodiments of the present disclosure provide compounds related to very long chain polyunsaturated fatty acids, pharmaceutical compositions containing the provided compounds, and methods of treating a subject with a condition or disease using provided compounds or pharmaceutical compositions.
Claims6
An eye drop formulation comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of:
- wherein n is 0 to 19;
- and
- the R group is selected from a group consisting of hydroxyl, methyl, ethyl, alkyl, or a cation forming a pharmaceutically acceptable salt selected from a group consisting of:
- ammonium cation, iminium cation, or a metal cation.
A controlled release formulation comprising:
- a controlled release system, a pharmaceutically acceptable carrier and a compound selected from the group consisting of:
- wherein n is 0 to 19;
- and
- the R group is selected from a group consisting of hydroxyl, methyl, ethyl, alkyl, or a cation forming a pharmaceutically acceptable salt selected from a group consisting of:
- ammonium cation, iminium cation, or a metal cation.
A sustained release pharmaceutical formulation comprising a sustained release matrix and a compound selected from the group consisting of:
- wherein n is 0 to 19;
- and
- the R group is selected from a group consisting of hydroxyl, methyl, ethyl, alkyl, or a cation forming a pharmaceutically acceptable salt selected from a group consisting of:
- ammonium cation, iminium cation, or a metal cation.
A method of treating stroke in a subject in need thereof, wherein the method comprises administering to the subject an effective amount of the compound and a pharmaceutically acceptable carrier, wherein the compound is selected from the group consisting of:
- wherein n is 0 to 19;
- and
- the R group is selected from a group consisting of hydroxyl, methyl, ethyl, alkyl, or a cation forming a pharmaceutically acceptable salt selected from a group consisting of:
- ammonium cation, iminium cation, or a metal cation.
Dependencies are inferred from the claim text.