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AssigneeThe Regents of the University of California
InventorsR. Michael van Dam, Jia Wang, Alejandra Rios, Philip Chao, Jason Jones
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A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization.
A high throughput radiochemistry system comprising:
The system of 1, further comprising a priming sensor, the priming sensor comprising a notch or partial opening and a light beam emitter and receiver disposed across the notch or partial opening.
Dependencies are inferred from the claim text.