Systems and methods for modulation and mapping of brain tissue using an ultrasound assembly

A method for modulation of brain tissue in a head of a subject using an ultrasound assembly comprising a housing configured to be secured to the head of the subject and an ultrasound transducer joined to the housing, the method comprising:

• securing the housing to the head of the subject with the ultrasound transducer aligned with a region of the brain tissue to target the region of the brain tissue for modulating;
• targeting the region of the brain tissue based on neuronavigation;
• providing focused ultrasound at an acoustic pressure to the targeted region using the ultrasound transducer to induce cavitation proximate to the targeted region;
• detecting a cavitation signal magnitude from the induced cavitation corresponding to the acoustic pressure;
• mapping the cavitation signal magnitude and comparing the cavitation signal magnitude to a threshold cavitation signal magnitude;
• and
• modulating the targeted region to a predetermined target value without cavitation signal magnitude exceeding the threshold cavitation signal magnitude, wherein the predetermined target value corresponds to at least one of an acoustic pressure and an opening volume of the brain tissue.