Sprayable tissue adhesive with biodegradation for wound treatment
AssigneesUniversity of Maryland, College Park, Children's National Medical Center
InventorsMetecan Erdi, Peter Kofinas, Omar B. Ayyub, Anthony Sandler, Michele Saruwatari
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Abstract
Provided are compositions and methods that involve viscoelastic poly(lactide-co-caprolactone) (PLCL) mixtures for use in wound healing. The PLCL mixtures provide an improved anti-fibrotic yet tissue-adhesive polymer sealant. The PLCL mixtures can be applied to a variety of wounds arising from surgical and non-surgical tissue damage.
Claims1
A composition consisting essentially of a mixture of 40 k and 5 k poly(L-lactide-co-caprolactone) (PLCL), wherein the 40 k and 5 k PLCL are present in a 70:30 mass ratio, respectively, wherein the composition is free of poly(lactic-co-glycolic acid) (PLGA), poly(ethylene glycol) (PEG) and nanoparticles, and when in contact with a tissue wound the composition is optionally a solid adhesive.
Dependencies are inferred from the claim text.