Cyclodextrin complexes of specialized proresolving mediators
AssigneeThetis Pharmaceuticals LLC
InventorsGary Mathias, Frank C. Sciavolino, Robert Lipper
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Abstract
The present invention provides complexes of a specialized pro-resolving mediator (SPM), or a salt, ester, or amide thereof, and a cyclodextrin (CD), wherein the SPM is a hydroxylated, polyunsaturated fatty acid derived from arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, or docosapentaenoic acid, 20 or 22 carbon atoms in length, with 4, 5 or 6 conjugated double bonds arranged in diene, triene, or tetraene systems or combinations thereof; and related compositions and methods.
Claims18
A complex of a resolvin E1 (RvE1), or a salt, ester, or amide thereof, and gamma-cyclodextrin (gamma-CD), wherein the molar ratio of RvE1 to gamma-CD in the complex is 1:1.
A complex of RvE1 MgLys and gamma-cyclodextrin (gamma-CD), wherein the molar ratio of RvE1 to gamma-CD in the complex is 1:1.
A complex of a sodium salt of RvE1 and gamma-cyclodextrin (gamma-CD), wherein the molar ratio of RvE1 to gamma-CD in the complex is 1:1.
Dependencies are inferred from the claim text.