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US 12,564,640 B2Granted
Protein-antiviral compound conjugates
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAlina Baum, Thomas Nittoli
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Abstract
Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with influenza, including VX-787 and derivatives thereof, baloxavir and derivatives thereof, and baloxavir marboxil and derivatives thereof, and protein (e.g., antibody) drug conjugates thereof.
Claims19
A compound selected from the group consisting of:
- wherein:
- L is a linker;
- BA is a binding agent,
- wherein the binding agent is an antibody or an antigen binding fragment thereof;
- and
- k is an integer from one to thirty.
3 more elements
A linker-payload compound selected from:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- SP1 and SP2, when present, are spacer groups;
- RG is a reactive moiety that binds to an antibody or antigen binding fragment thereof:
- each AA is an amino acid;
- and
- n is an integer from one to ten.
4 more elements
Dependencies are inferred from the claim text.