Cationic nanostructures for intra-cartilage delivery of contrast agents and diagnostic uses thereof
AssigneeNortheastern University
InventorsAmbika Bajpayee, Chenzhen Zhang, Armin Vedadghavami, Tengfei He
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Abstract
The present invention provides a platform for the delivery of small molecule drugs or contrast agents to joints and other soft tissues. The platform enables penetration of the drug through the full thickness of cartilage and long intra-cartilage residence time by leveraging electrostatic interactions between the cationic platform and the anionic cartilage matrix. Described herein are compounds and complexes that fit this platform. Also provided are methods of treating a joint disease with the compounds and complexes of the invention, and methods of imaging joints and other soft tissue.
Claims13
A complex, comprising:
- a residue of a contrast agent and a cationic peptide;
- wherein the net charge of the cationic peptide is +7 to +20 inclusive;
- the residue of the contrast agent is covalently bonded to the cationic peptide;
- the contrast agent is selected from the group consisting of diatrizoate, metrizoate, iothalamate, and ioxaglate;
- and
- the cationic peptide is selected from the group consisting of:
- RRAAAARRAAAARRAAAARR (SEQ ID NO:
- 1);
- RRRRAARRRAARRRAARRRR (SEQ ID NO:
- 2);
- (ARRRAARA)4 (SEQ ID NO:
- 3);
- and
- RRRRRRRRRRRRRRRRRRRR (SEQ ID NO:
- 4).
A complex, comprising:
- a residue of a contrast agent and a cationic peptide;
- wherein the net charge of the cationic peptide is +7 to +20 inclusive;
- the residue of the contrast agent is covalently bonded to the cationic peptide;
- and
- the cationic peptide is selected from the group consisting of:
- RRAAAARRAAAARRAAAARR (SEQ ID NO:
- 1);
- RRRRAARRRAARRRAARRRR (SEQ ID NO:
- 2);
- (ARRRAARA)4 (SEQ ID NO:
- 3);
- and
- RRRRRRRRRRRRRRRRRRRR (SEQ ID NO:
- 4).
Dependencies are inferred from the claim text.