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US 12,564,636 B2Granted
Pnictogen-containing heterocyclic compounds and their use
AssigneesUniversity of Rhode Island Board of Trustees, Colgate University
InventorsFang Wang, Jacob M. Goldberg, Bradley M. Lipka, Daniel S. Honeycutt
Life of this patent
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Abstract
Disclosed are pnictogen-containing heterocyclic compounds of Formula (I) Each of R1, the heterocyclic ring H, A+, LG, and X− is defined herein. Also provided are methods of modifying a substrate using such a compound, conjugated biomolecules thus modified, and pharmaceutical compositions containing one of the conjugated biomolecules.
Claims17
A pnictogen-containing heterocyclic compound of Formula (I):
- in which
- R1 is C1-C6 alkyl, C4-C10 cycloalkyl, 5- to 8-membered heterocycloalkyl, aryl, or heteroaryl;
- is a heterocyclic ring;
- A+ is a cationic quaternary pnictogen atom;
- LG is a leaving group selected from the group consisting of halogen, aryloxy, RaO2S—, RbO2S—O—, RcOS—, RdS(O)(NSO2Re)—, and RfS(O)(N+(CH3)2)-, each of Ra, Rb, Rc, Rd, Re, and Rf, independently, being C1-C6 alkyl, aryl, heteroaryl, halogen, alkoxy, or aryloxy;
- X− is a counter anion selected from the group consisting of halide, polyhalide anion, perchlorate, hydroxide, peroxide, siloxide, sulfate, hydrogen sulfate, sulfite, disulfite, dithionate, dithionite, halosulfate, thiosulfate, persulfate, disulfate, sulfinate (R′SO2−), sulfonate (R″SO3−), bis(sulfonyl)imide ((R′SO2)2N−), nitrate, nitrite, azide, cyanide, cyanate, thiocyanate, phosphate, metaphosphate, polyphosphate, hydrogen phosphate, dihydrogen phosphate, monohalophosphate, dihalophosphate, hexahalophosphate, organophosphonate (R′P(O)(O−)2 or R′P(O)(OR−) (O−)), organophosphate (R′OP(O)(O)2 or R′OP(O)(OR″)(O−)), arsenate, alkoxide, alkenoxide, aryloxide, carboxylate, percarboxylate, carbonate, bicarbonate, oxalate, borate, tetrahaloborate, tetraalkylborate, tetraarylborate, carborane, and combinations thereof, each of R′ and R″, independently, being C1-C6 alkyl or aryl;
- and
- the number of net negative charges of X″ equals to that of the net positive charges of
5 more elements
Dependencies are inferred from the claim text.