Serum free intracellular pathogen vaccine
AssigneeIntervet Inc.
InventorsJoseph Koumans, Petter Frost, Maria Forlenza
Life of this patent
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Abstract
A vaccine composition comprising a virus antigen wherein the composition comprises less than 5% serum, wherein the virus antigen is a whole virus or derived from a whole virus, the vaccine composition reduces, prevents or avoids cross-stitch spinal deformity in the treated animal. Said vaccine composition for use in a method of treating a disease caused by the intracellular pathogen in an animal and reducing, preventing or avoiding cross-stitch spinal deformity in the treated animal. In cross-stitch vertebra the intervertebral space is completely collapsed. A vaccine composition for use as defined above wherein the animal is a fish. In an embodiment the pathogen is salmon alpha virus (SAV).
Claims12
A method for administering a vaccine composition to fish comprising:
- administering to a fish in need thereof, a vaccine composition comprising:
- an antigen from an intracellular pathogen, and;
- less than 5% serum, wherein the less than 5% serum prevents or ameliorates in the fish the occurrence of a spinal deformity associated with the administration of the vaccine composition, wherein the spinal deformity is characterized by a complete collapse of the intervertebral space;
- wherein:
- the vaccine comprises less than 2.5 g/L of albumin,
- the antigen is a whole intracellular pathogen or an antigen obtained from a whole intracellular pathogen;
- the intracellular pathogen is a salmon pathogen;
- and
- the intracellular pathogen has been grown on cell culture.
Dependencies are inferred from the claim text.