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US 12,564,625 B2Granted
Method of producing pharmaceutical compositions comprising immunogenic chikungunya virus CHIKV-Δ5nsP3
AssigneeValneva SE
InventorsAndrea Fritzer, Andreas Meinke, Urban Lundberg, Mario Nebenführ, Jürgen Heindl-Wruss, Robert Schlegl, Arnaud Leon
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Abstract
The present invention relates to a process for producing an immunogenic live attenuated Chikungunya virus, as well as pharmaceutical compositions comprising the same.
Claims20
A pharmaceutical composition comprising chikungunya virus (CHIKV)-Δ5nsP3 particles, wherein said pharmaceutical composition comprises:
- (i) at least 103 CHIKV-Δ5nsP3 particles which express an E2 structural protein as defined by the amino acid sequence of SEQ ID NO:
- 2;
- and
- (ii) 1-70% CHIKV-Δ5nsP3 particles which express an E2 structural protein having at least one mutation compared with the amino acid sequence of SEQ ID NO:
- 2,
- wherein said at least one mutation is selected from the group consisting of E168K, E247K, H99Y, G55R, H232Y and T230I.
3 more elements
Dependencies are inferred from the claim text.