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US 12,564,583 B2Granted
Small molecules against cereblon to enhance effector T cell function
AssigneeLee Moffitt Cancer Center and Research Institute, Inc.
InventorsPearlie Burnette, Harshani Lawrence, Nicholas J. Lawrence
Life of this patent
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Abstract
Disclosed are small molecules against cereblon to enhance effector T cell function. Methods of making these molecules and methods of using them to treat various disease states are also disclosed.
Claims7
A composition comprising a compound having a structure represented by Formula I:
- wherein,
- Ar is aryl, heteroaryl, cycloalkyl, or heterocyclyl;
- L is —SO2;
- R1, R2, and R3 are individually selected from the group consisting of hydrogen, halogen, hydroxyl, azide, alkoxyl, sulfhydryl, imino, amido, phosphonate, phosphinate, carbonyl, carboxyl, cyano, silyl, ether, alkylthio, sulfonyl, sulfonamido, ketone, aldehyde, amine, amide, nitro, ester, morpholino, dioxolane, alkyl, alkylhalide, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl;
- cycloalkenyl, aryl, heteroaryl, arylalkyl, heteroalkyl, and combinations thereof
- R4 and R5 are individually selected from the group consisting of hydrogen, halogen, hydroxyl, azide, alkoxyl, sulfhydryl, alkylthio, sulfonamido, alkyl, alkylhalide, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, and combinations thereof;
- R8 is selected from the group consisting of hydrogen, alkyl, alkylhalide, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, alkylaryl, and combinations thereof;
- the bond --- is present or absent;
- and
- x is 1.
7 more elements
Dependencies are inferred from the claim text.