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US 12,564,560 B1Granted
Selective serotonin receptor modulators and methods of making and using the same
AssigneePark City Bio, LLC
InventorJeremy Forest
Life of this patent
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Abstract
This disclosure relates to serotonin receptor modulators, including conformationally constrained serotonin receptor agonists, and methods of making and using the same are disclosed herein.
Claims29
A method of treating staring spells and/or loss of awareness associated with thalamocortical oscillations, comprising orally administering to a human subject in need thereof at least one compound selected from compounds of Formula V:
- wherein
- X and Y are each hydrogen;
- W1 is O;
- W3 is —C(R10)(R11) wherein n is an integer selected from 1 to 4;
- W4 is
- wherein m is 0 or 1;
- R10, R11, R12, and R13 are, for each occurrence, independently selected from hydrogen, deuterium, and fluoro;
- R15 is selected from hydrogen, deuterium, and fluoro;
- R4, R6, and R7 are each hydrogen;
- R5 is fluoro;
- R3 and R3′ are each, independently, selected from hydrogen and deuterium;
- and salts, solvates, hydrates, prodrugs, and enantiomers thereof.
9 more elements
Dependencies are inferred from the claim text.