Retrievable self-expanding non-thrombogenic low-profile percutaneous atrioventricular valve prosthesis

An atrioventricular prosthesis device comprising:

• a frame comprising a plurality of flexible elongated members, the frame being configured to transition from a contracted position, where the frame is configured to be disposed within a catheter tube, to a deployed position, where the frame defines a central cavity having a width which substantially conforms to a diameter of a tricuspid and/or mitral valve opening;
• and
• a valve construct mounted to the frame and spanning at least a portion of the central cavity defined by the frame, the valve construct comprising:
• an annular portion defining an aperture connected to at least one of the plurality of elongated members, and
• a plurality of leaflets each comprising a central region and a commissure region, the leaflets extending longitudinally and radially inwardly from the annular portion,
• wherein one or more of the plurality of leaflets of the valve construct comprise a plurality of synthetic, electrospun polymer fibers deposited in an anisotropic orientation forming a non-woven, porous mesh, and
• wherein the central region and/or the commissure region of the plurality of leaflets comprise a matrix formed from the plurality of synthetic polymer fibers.