US 12,564,202 B2Granted

Composition for alleviating, preventing or treating sarcopenia, containing whey protein hydrolysate as active ingredient

AssigneeNeo Cremar Co., Ltd.

InventorsHyoung Su Park, Jae Hwan Kim, Joong-chul Shin, Seung-Il Ahn, Se Young Jung, Seok Jun Park, Jung Sik Park

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Abstract

The present disclosure relates to a composition for alleviating, preventing or treating sarcopenia, containing, as an active ingredient, a whey protein hydrolysate, obtained by performing, on whey protein, primary hydrolysis using a Bacillus licheniformis-derived endoprotease and secondary hydrolysis using an Aspergillus oryzae-derived exoprotease, which inhibits protein degradation and activates protein synthesis through the PI3K-Akt pathway, thereby reducing muscle loss and increasing muscle size and muscle strength.

Claims10

Dependent claims

A method for preparing a water-soluble whey protein hydrolysate, comprising:

(A) a step of dissolving whey protein by mixing the whey protein with water at a weight ratio of 1:3-10;
(B) a step of performing primary hydrolysis by adding 0.1-1 part by weight of a Bacillus licheniformis-derived endoprotease to 100 parts by weight of the dissolved whey protein;
(C) a step of performing secondary hydrolysis by adding 0.1-1 part by weight of an Aspergillus oryzae-derived exoprotease to the primarily hydrolyzed hydrolysate;
and
(D) a step of obtaining a water-soluble whey protein hydrolysate by filtering the secondarily hydrolyzed hydrolysate to remove an insoluble substance,
wherein the Bacillus licheniformis-derived endoprotease is a mixture of Alcalase and Protamex, where a weight ratio of the Alcalase and the Protamex is 1:0.5-2,
wherein Aspergillus oryzae-derived exoprotease is Flavourzyme, and
wherein a weight ratio of the mixture of Alcalase and Protamex to Flavourzyme is 2:1.

5 more elements

Dependencies are inferred from the claim text.