Shaking block, shaking device comprising detachable module, and liquid handling system comprising same

A separation device for separating a target substance bound to magnetic particles from a sample, comprising:

• a magnetic block including a magnetic plate, a vertical movement mechanism for transferring the magnetic plate up and down in a vertical direction to control a vertical position of the magnetic plate, and a casing which accommodates the vertical movement mechanism and the magnetic plate;
• and
• a shaking block coupled to a lower portion of the magnetic block and configured to transmit a rotational force through a bearing coupling portion to the magnetic block such that the magnetic block performs orbital motion,
• wherein the magnetic block and the shaking block are vertically coupled together by a plurality of elastic fasteners,
• the magnetic block and the shaking block are vertically spaced apart from each other and are directly connected only by the bearing coupling portion and the plurality of elastic fasteners, and
• the plurality of elastic fasteners couple the magnetic block with the shaking block such that relative positions thereof are variable by a predetermined deviation,
• wherein each of the plurality of elastic fastener includes an elastic member and first and second fastening members respectively coupled to upper and lower sides of the elastic member, and
• the vertical movement mechanism includes a moving motor fixed inside the casing, a link connected to a rotation shaft of the moving motor to convert rotational motion of the moving motor into vertical motion, and a fixing member connecting the link to the magnetic plate.

A separation device for separating a target substance bound to magnetic particles from a sample, comprising:

• a magnetic block including a magnetic plate, a vertical movement mechanism for transferring the magnetic plate up and down in a vertical direction to control a vertical position of the magnetic plate, and a casing which accommodates the vertical movement mechanism and the magnetic plate;
• and
• a shaking block coupled to a lower portion of the magnetic block and configured to transmit a rotational force through a bearing coupling portion to the magnetic block such that the magnetic block performs orbital motion,
• wherein the magnetic block and the shaking block are vertically coupled together by a plurality of elastic fasteners,
• the magnetic block and the shaking block are vertically spaced apart from each other and are directly connected only by the bearing coupling portion and the plurality of elastic fasteners, and
• the plurality of elastic fasteners couple the magnetic block with the shaking block such that relative positions thereof are variable by a predetermined deviation,
• wherein each of the plurality of elastic fasteners is bolts with an elastic member between the bolts, and the elastic member is rubber or silicone, and
• the vertical movement mechanism includes a moving motor fixed inside the casing, a link connected to a rotation shaft of the moving motor to convert rotational motion of the moving motor into vertical motion, and a fixing member connecting the link to the magnetic plate.

A separation device for separating a target substance bound to magnetic particles from a sample, comprising:

• a magnetic block including a magnetic plate, a vertical movement mechanism for transferring the magnetic plate up and down in a vertical direction to control a vertical position of the magnetic plate, and a casing which accommodates the vertical movement mechanism and the magnetic plate;
• and
• a shaking block coupled to a lower portion of the magnetic block and configured to transmit a rotational force through a bearing coupling portion to the magnetic block such that the magnetic block performs orbital motion,
• wherein the magnetic block and the shaking block are vertically coupled together by a plurality of elastic fasteners,
• the magnetic block and the shaking block are vertically spaced apart from each other and are directly connected only by the bearing coupling portion and the plurality of elastic fasteners, and
• the plurality of elastic fasteners couple the magnetic block with the shaking block such that relative positions thereof are variable by a predetermined deviation,
• wherein the shaking block includes:
• a housing;
• a rotary motor fixed to the housing;
• an eccentric cam fixedly coupled to a shaft of the rotary motor;
• and
• a bearing,
• wherein the plurality of elastic fasteners are positioned symmetrically to each other on outer sides of the housing,
• the housing is coupled to the casing by the plurality of elastic fasteners, and
• the shaft of the rotary motor is eccentric from the center of the bearing by the eccentric cam, an outer diameter of the bearing is fixed to a bottom portion of the casing, thereby a rotational force of the rotary motor causes orbital shaking of the magnetic block and a well plate, which is detachably seated on the magnetic block, through the eccentric cam and the bearing.