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US 12,560,612 B2Granted
Ultra bright dimeric or polymeric dyes with spacing linker groups
AssigneeSony Group Corporation
InventorsTracy Matray, Sharat Singh
Life of this patent
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Abstract
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
Claims22
A compound having the following structure (IA):
- or a stereoisomer, salt or tautomer thereof, wherein:
- M comprises aromatic rings selected from aryl and heteroaryl rings, wherein the aromatic rings include multiple degrees of conjugation;
- L1 is at each occurrence, independently either:
- i) an alkylene or heteroalkylene linker;
- or ii) a linker comprising a triazolyl functional group;
- L2 and L3 are, at each occurrence, independently an optional alkylene or heteroalkylene linker;
- R1 is, at each occurrence, independently H;
- R2 and R3 are each independently OH, —OP(═Ra)(Rb)Rc, Q, or a protected form thereof, or L′;
- R4 is, at each occurrence, independently OH, O−, ORd;
- R5 is, at each occurrence, independently oxo;
- Ra is O;
- Rb is OH, O−, or ORd;
- Rc is OH, O−, ORd or OL′;
- Rd is a counter ion;
- Q comprises a sulfhydryl, activated ester, or maleimide functional group;
- L′ is, at each occurrence, independently a linker comprising a covalent bond to Q, a linker comprising a covalent bond to a targeting moiety, a linker comprising a covalent bond to an analyte molecule, a linker comprising a covalent bond to a solid support, a linker comprising a covalent bond to a solid support residue, a linker comprising a covalent bond to a nucleoside or a linker comprising a covalent bond to a further compound of structure (IA);
- m is, at each occurrence, independently an integer of zero to 10, wherein at least one occurrence of m is an integer of one to 10;
- n is an integer of one to 32;
- and
- z is an integer from three to 100.
17 more elements
Dependencies are inferred from the claim text.