Point of care device for early and rapid disease diagnosis

A system comprising:

• a device with a collection region, wherein the device is configured to hold a sample that is combined with a fluorescent dye and a plurality of magnetic particles such that disease components in the sample are tagged with the fluorescent dye and the plurality of magnetic particles, wherein the device is configured to be rotated such that the collection region is at a bottom of the device after the sample is combined with the fluorescent dye and the plurality of magnetic particles;
• at least one magnet, removeably positioned near the collection region, configured to establish a magnetic field gradient to draw the tagged disease components into the collection region of the device when the magnet is positioned near the collection region, wherein the magnet is configured to hold the tagged disease component in the collection region while non-magnetic parts of the sample are removed from the device, and wherein the magnet is configured to be removed from near the collection region when the non-magnetic parts of the sample have been removed;
• and
• a fluorescence microscope configured to be positioned near the collection region in place of the at least one magnet, when the magnet has been removed, and to image the collection region using the fluorescent dye to detect the tagged disease components, wherein the fluorescence microscope uses light to excite the fluorescent dye and a filter to transmit light emitted by the fluorescent dye to the fluorescence microscope, while restricting light used to excite the fluorescent dye.