US 12,560,569 B2Granted

Techniques for performing optical and electrochemical assays with universal circuitry

AssigneeAbbott Point of Care Inc.

InventorsMichael Louie Low, Barry Bass, Sergey Gershtein

Life of this patent

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Abstract

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

Claims5

Dependent claims

A method comprising:

receiving an operating state signal from a test cartridge indicative of a type of test cartridge inserted into an analyzer, wherein the analyzer comprises:
a multi-terminal connector comprising a first pin and a second pin, the first pin and the second pin electrically connectable to contacts of the test cartridge, and a universal channel circuitry comprising a first channel and a second channel, the first channel comprises first circuitry comprising one or more switches, and the second channel comprises second circuitry comprising one or more switches;
determining, based on the type of test cartridge, that the test cartridge has a first contact of the contacts that is connected to a light emitter and a second contact of the contacts that is connected to a light detector;
in response to determining the first contact is connected to the light emitter, assigning the first channel to the light emitter via the first contact and the first pin;
in response to determining the second contact is connected to the light detector, assigning the second channel to the light detector via the second contact and the second pin;
switching the first circuitry of the first channel to a current driver mode using the one or more switches of the first circuitry;
switching the second circuitry of the second channel to a current measurement mode using the one or more switches of the second circuitry;
applying, using the first channel in the current driver mode, a drive current to the light emitter;
converting, using the second channel in the current measurement mode, an output signal received from the light detector to an analyte signal proportional to an amount of light detected by the light detector;
and
determining a qualitative, semi-quantitative, or quantitative value proportional to an amount of analyte in a biological sample in the test cartridge based on the analyte signal.

8 more elements

A method comprising:

receiving an operating state signal from a test cartridge indicative of a type of test cartridge inserted into an analyzer, wherein the analyzer comprises:
a multi-terminal connector comprising a first pin and a second pin, the first pin and the second pin electrically connectable to contacts of the test cartridge, and a universal channel circuitry comprising a first channel and a second channel, the first channel comprises first circuitry comprising one or more switches, and the second channel comprises second circuitry comprising one or more switches;
determining, based on the type of test cartridge, that the test cartridge has a first contact of the contacts that is connected to a first conductometric electrode and a second contact of the contacts that is connected to a second conductometric electrode;
in response to determining the first contact is connected to the first conductometric electrode, assigning the first channel to the first conductometric electrode via the first contact and the first pin;
in response to determining the second contact is connected to the second conductometric electrode, assigning the second channel to the light detector via the second contact and the second pin;
switching the first circuitry of the first channel to a high conductometric mode using the one or more switches of the first circuitry;
switching the second circuitry of the second channel to a low conductometric mode using the one or more switches of the second circuitry;
applying, using the first channel in the high conductometric mode, a potential to the first conductometric electrode;
measuring, using the first channel in the high conductometric mode and the second channel in the low conductometric mode, a voltage change across the biological sample that is proportional to conductivity of the biological sample;
and
determining a position of the biological sample within the test cartridge based on the voltage change across the biological sample.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/350,426Filed 17 Jun 2021 · continuation
Priority: 17 Aug 2017
Published: US 2021/0310978 A17 Oct 2021
Granted: 24 Feb 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification26 codes

G01N 27/3271
Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements: amperometric enzyme electrodes for analytes in body…
B01L 3/502715
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/502753
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/545
Labware with identification means: for laboratory containers

Family

Application62/546,731Us provisional application · filed 17 Aug 2017
Application16/104,204Parent of this continuation · filed 17 Aug 2018
US 2021/0310978 A1Pre-grant publication · published 7 Oct 2021
US 11,060,994 B2Parent of this continuation
US 2019/0056342 A1Published application
US 12,560,569 B2This patent

From the US filing history. Foreign family members aren’t listed.