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US 12,559,769 B2Granted
Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells
AssigneeAmerican Gene Technologies International Inc.
InventorsCharles David Pauza, Tyler Lahusen, Haishan Li, Mei-Ling Liou, Lingzhi Xiao
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Abstract
The present disclosure relates generally to methods and compositions for activating gamma-delta (GD) T cells. Such methods and compositions can be used to treat cancer.
Claims8
A viral vector, comprising at least one encoded RNA that, when expressed, inhibits production of at least one enzyme of the mevalonate pathway, further comprising at least one of an encoded butyrophilin family member, an encoded cytokine, or an encoded chemokine,
- wherein the at least one encoded RNA comprises a sequence having at least 95% identity with at least one of SEQ ID NO:
- 64;
- SEQ ID NO:
- 65;
- SEQ ID NO:
- 66;
- or SEQ ID NO:
- 67.
5 more elements
Dependencies are inferred from the claim text.