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US 12,559,759 B2Granted
Fusion polypeptides
AssigneeDanisco US Inc.
InventorsJimmy Chan, David A. Estell, Amy Deming Liu, Michael C. Miller, Igor Nikolaev
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Abstract
Provided herein, inter alia, are fusion DNA constructs comprising improved protease recognition sequences for expressing and purifying one or more polypeptides of interest as well as methods for producing one or more polypeptides of interest in a recombinant host cell.
Claims7
A fusion polypeptide comprising a KEX2 region, wherein the amino acid sequence of the KEX region comprises TKVAVEKRQV (SEQ ID NO:10), wherein the amino acid sequence is completely cleaved by one or more protease(s) and wherein the protease is a Kex2 serine peptidase (EC 3.4.21.61).
Dependencies are inferred from the claim text.