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US 12,559,732 B2Granted
Compositions and methods for producing human milk oligosaccharides
AssigneeNorth Carolina State University
InventorsJose M. Bruno-Barcena, Suzanne Dagher, Maria Andrea Azcarate-Peril
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Abstract
The present disclosure provides compositions and methods related to the production of human milk oligosaccharides (HMOs). In particular, the present disclosure provides compositions and methods for converting lactose and N-acetylglucosamine (GlcNAc) into N-acetyllactosamine (LacNAc)-enriched galactooligosaccharide (GOS) compositions using novel β-hexosyl-transferase (BHT) enzymes.
Claims16
A functional, recombinant β-hexosyl-transferase (rBHT) polypeptide comprising at least 90% sequence identity with SEQ ID NO:
- 1 and an N-terminal truncation of 56 amino acids to 81 amino acids in length, with reference to SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.