Isoform-independent antibodies to lipoprotein(a)
AssigneeThe Regents of the University of California
InventorsSotirios Tsimikas, Joseph L. Witztum, Ayelet Gonen
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Abstract
The disclosure provides for antibody and antibody fragments that bind to lipoprotein(a) epitopes and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic and diagnostic agents for treating diseases and disorders associated with Lp(a).
Claims17
An antibody or antibody fragment that recognizes and binds to lipoprotein(a), wherein the antibody or antibody fragment comprises a variable heavy chain (VH) domain and/or a variable light chain (VL) domain, and wherein (a) the VH domain comprises an amino acid sequence that includes complementarity determining regions (CDRs) of:
- SEQ ID NO:4;
- SEQ ID NO:6;
- and SEQ ID NO:8;
- and (b) the VL domain comprises an amino acid sequence that includes complementarity determining regions (CDRs) of:
- SEQ ID NO:12;
- KVS;
- and SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.