Multivalent DNA antibody constructs and use thereof
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsDavid Weiner, Ami Patel
Life of this patent
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Abstract
Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including a recombinant nucleic acid sequence that encodes an antibody, a synthetic antibody, or a synthetic multivalent antibody to a subject. The disclosure also provides compositions and methods of preventing and/or treating a bacterial infection in a subject using said antibody, synthetic antibody, or synthetic multivalent antibody.
Claims4
A nucleic acid molecule encoding one or more synthetic antibodies or fragment thereof, wherein the nucleic acid molecule comprises at least one selected from the group consisting of:
- a) a nucleotide sequence encoding a synthetic antibody, wherein the nucleotide sequence encodes an amino acid sequence that is at least about 80% identical to a sequence set forth in SEQ ID NO:
- 2 and an amino acid sequence that is at least about 80% identical to a sequence set forth in SEQ ID NO:
- 4;
- b) a nucleotide sequence encoding a synthetic antibody, wherein the nucleotide sequence encodes an amino acid sequence that is at least about 80% identical to a sequence set forth in SEQ ID NO:
- 2, an amino acid sequence that is at least about 80% identical to a sequence set forth in SEQ ID NO:
- 4, and an amino acid sequence that is at least about 80% identical to a sequence set forth in SEQ ID NO:
- 6;
- c) a nucleotide sequence encoding a fragment of a synthetic antibody, wherein the fragment of a synthetic antibody comprises a fragment of an amino acid sequence that is at least about 80% identical to SEQ ID NO:2 and a fragment of an amino acid sequence that is at least about 80% identical to SEQ ID NO:4;
- and
- d) a nucleotide sequence encoding a fragment of a synthetic antibody, wherein the fragment of a synthetic antibody comprises a fragment of an amino acid sequence that is at least about 80% identical to SEQ ID NO:2, a fragment of an amino acid sequence that is at least about 80% identical to SEQ ID NO:4, and a fragment of an amino acid sequence that is at least about 80% identical to SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.