Purine diones as Wnt pathway modulators
AssigneeAgency for Science, Technology and Research
InventorsSoo Yei Ho, Stephanie Eliane Blanchard, Athisayamani Jeyaraj Duraiswamy, Jenefer Alam, Vikrant Arun Adsool
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Abstract
The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
Claims4
A method of synthesizing a compound having structure (I)
- wherein:
- R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group;
- D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted;
- Ar is a 6-membered heteroaryl ring having 1 or 2 nitrogen atoms and having no substituents other than Cy and the amide nitrogen atom depicted in structure (I), the Cy and the amide nitrogen being in a 1,4-relationship on the ring;
- and
- Cy is an aryl, heteroaryl, or saturated ring containing at least one heteroatom, each being optionally substituted;
- and
- n is an integer from 1 to 2;
- or an enantiomer, diastereomer or salt thereof;
- comprising:
- reacting a compound of Formula (C)
- with a compound of Formula (D)
- wherein X is a halide, in order to form an intermediate, wherein a mole ratio of the compound of Formula (C) to the compound of Formula (D) is from 1:1.1 to 1:1.2.
Dependencies are inferred from the claim text.