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US 12,559,493 B2Granted
PGDH inhibitors and methods of making and using
AssigneeMyoforte Therapeutics, Inc.
InventorsRoopa Rai, Robert Booth, Michael J. Green
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin level.
Claims16
A compound having the structure of Formula IIa:
- or a pharmaceutically acceptable salt thereof, wherein:
- T is N and U is CR5;
- Y is N;
- R1 is selected from C3-10cycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
- wherein the alkyl, cycloalkyl, aryl, or heteroaryl is optionally substituted with 1 to 3 substituents independently selected from halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O)R8, —NR10C(O)NR6R7, —NR10SO2R8, —NR10SO2NR6R7, C1-6alkyl, C1-6heteroalkyly, C1-6haloalkyl, C3-10cycloalkyl, and 5- to 10-membered heteroaryl;
- R2 is H and R3 is —CF3;
- or
- R2 and R3 are taken together to form oxo or thio;
- each R4 is independently selected from halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O) R8, —NR10C(O)NR6R7, —NR10SO2R8, —NR10SO2NR6R7, C1-6alkyl, C1-6heteroalkyl, C1-6haloalkyl, C3-10cycloalkyl, 3- to 10-membered heterocycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
- or
- two R4 are taken together with the carbon atoms to which they are attached and any intervening atoms to form a C3-10cycloalkyl, and any remaining R4 are independently selected from halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O) R8, —NR10C(O)NR6R7, —NR10SO2R8, —NR10SO2NR6R7, C1-6alkyl, C1-6heteroalkyl, C1-6haloalkyl, C3-10cycloalkyl, 3- to 10-membered heterocycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
- each R5 is independently selected from H, halo, —NR6R7, —OR8, —C(O)R8, —C(O)OR8, —C(O)NR6R7, —SOR9, —SO2R9, —SO2NR6R7, —NR10C(O) R8, —NR10C(O)NR6R7, —NR10SO2R8, —NR10SO2NR6R7, C1-6alkyl, C1-6heteroalkyl, C1-6haloalkyl, C3-10cycloalkyl, 3- to 10-membered heterocycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
- R6 and R7 are independently selected at each occurrence from H, C1-6alkyl, C1-6heteroalkyl, C1-6haloalkyl, and C3-10cycloalkyl;
- each R8 is independently selected from H, C1-6alkyl, C1-6heteroalkyl, C1-6haloalkyl, C3-10cycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
- each R9 is independently selected from C1-6alkyl, C1-6heteroalkyl, C1-6haloalkyl, C3-10cycloalkyl, C6-10aryl, and 5- to 10-membered heteroaryl;
- each R10 is independently selected from H, C1-6alkyl, C1-6haloalkyl, and C3-10cycloalkyl;
- and
- m is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;
- and
- p is 0, 1, or 2.
17 more elements
Dependencies are inferred from the claim text.