Cell penetrating cyanine-coupled antibodies

A method of delivering a cell penetrating conjugate into a cell comprising administering to a cell a cell-penetrating conjugate of formula:

• wherein
• R1, R2, R3 and R4 are independently hydrogen, halogen, —CX3, —CN, —C(O)OH, —CH2C(O)OH, —C(O)NH2, —OH, —SH, —NO2, —NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —SO3H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• X is —F, —Cl, —Br, or —I;
• L1 is substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene;
• P is a STAT3 antibody, wherein said STAT3 antibody is non-cell penetrating if not attached to the remainder of the compound of formula (II) or (V);
• n is 1 or 2;
• z1 and z2 are independently 1 or 2;
• wherein said cell is an intact cell;
• wherein said antibody binds an intracellular target in said intact cell;
• wherein said intracellular target is a therapeutic target of cancer located intracellularly;
• and
• wherein said intracellular target is not HER2, thereby delivering said cell penetrating conjugate into said cell.