Back to results
US 12,559,472 B2Granted
Salts of a compound and the crystalline forms thereof
AssigneeHutchison Medipharma Limited
InventorsWenji Li, Ling Feng
Life of this patent
Estimating the term…
Abstract
The present invention relates to the salts of a compound and the crystalline forms thereof. More specifically, the present invention belongs to the pharmaceutical field, and provides the pharmaceutically acceptable salts of the compound.
Claims16
A salt of Formula A:
- wherein
- (i) n is 1 and M is hydrochloric acid, and the salt is Form A-III having the X-ray powder diffraction characteristic diffraction angles (2θ) of 5.8±0.2°, 6.2±0.2°, 12.3±0.2°, 13.3±0.2°, 23.1±0.2°, and 24.1±0.2°;
- (ii) n is 0.5 and M is tartaric acid, and the salt is Form B-II having the X-ray powder diffraction characteristic diffraction angles (2θ) of 7.5±0.2°, 11.3±0.2°, 13.9±0.2°, 15.1±0.2°, 18.0±0.2°, and 20.6±0.2°;
- (iii) n is 0.5 and M is tartaric acid, and the salt is Form B-III having the X-ray powder diffraction characteristic diffraction angles (2θ) of 13.1±0.2°, 14.6±0.2°, 18.3±0.2°, 18.9±0.2°, 19.4±0.2°, and 26.3±0.2°;
- or
- (iv) n is 1 and M is p-toluenesulfonic acid, and the salt is Form C-I having the X-ray powder diffraction characteristic diffraction angles (2θ) of 7.8±0.2°, 11.1±0.2°, 11.7±0.2°, 16.6±0.2°, 17.9±0.2°, 18.2±0.2°, 19.2±0.2°, and 24.0±0.2°.
3 more elements
Dependencies are inferred from the claim text.