Quinazolinone dione compounds and uses thereof

A compound represented by Formula (Ia):

• or a salt thereof, wherein:
• X1 is selected from C(R1a), N, and N+(—O−);
• X2 is selected from C(R1b), N, and N+(—O−);
• X3 is selected from C(R1c), N, and N+(—O−);
• X4 is selected from C(R1d), N, and N+(—O−);
• wherein no more than two of X1, X2, X3, and X4 are N or N+(—O−);
• U is absent or selected from —O−;
• Y2 is selected from C(R9bB), N, and N+(—O−);
• Y4 is selected from C(R9bD), N, and N+(—O−);
• Y5 is selected from C(R9bE), N, and N+(—O−);
• wherein no more than two of Y2, Y4, and Y5 are N or N+(—O−);
• R1a, R1b, and R1c are each independently selected from:
• hydrogen;
• halogen, —NO2, —N3, —CN, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, and —S(O)2R10a;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —C(O)OR10a, —OC(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9a;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9a;
• R1d is selected from:
• hydrogen;
• NO2, —N3, —CN, —OR10a, —SR10a—N(R10a)2, —C(O)R10a-C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, and —S(O)2R10a;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —C(O)OR10a, —OC(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —S(O)R10a, —S(O)2R10a, —NO2, —O, ═S, —N(R10a), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9a;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9a;
• RZ is selected from:
• CN, —C(O)R10z, —C(O)N(R10z)2, and —C(O)OR10z;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10z—SR10z, —N(R10z)2, —C(O)R10z, —C(O)N(R10z)2, -N(R10z)C(O)R10z, —C(O)OR10z, —OC(O)R10z, —N(R10z)C(O)N(R10z)2, —OC(O)N(R10z)2, —N(R10z)C(O)OR10z, —S(O)R10z, —S(O)2R10z, —NO2, ═O, ═S, ═N(R10z), —N3, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9z;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10z, —SR10z, —N(R10z)2, —C(O)R10z, —C(O)N(R10z)2, —N(R10z)C(O)R10z, —N(R10z)C(O)N(R10z)2, —OC(O)N(R10z)2, —N(R10z)C(O)OR10z, —C(O)OR10z, —OC(O)R10z, —S(O)R10z, —S(O)2R10z, —NO2, ═O, ═S, ═N(R10z), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9z;
• RC is selected from:
• hydrogen;
• CN, —C(O)R10c, —C(O)N(R10c)2, and —C(O)OR10c;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10c, —SR10c, —N(R10c)2, —C(O)R10c, —C(O)N(R10c)2, —N(R10c)C(O)R10c, —C(O)OR10c, —OC(O)R10c, —N(R10c)C(O)N(R10c)2, —OC(O)N(R10c)2, —N(R10c)C(O)OR10c, —S(O)R10c, —S(O)2R10c, —NO2, ═O, ═S, ═N(R10c), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9c;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10c, —SR10c, —N(R10c)2, —C(O)R10c, —C(O)N(R10c)2, —N(R10c)C(O)R10c, —N(R10c)C(O)N(R10c)2, —OC(O)N(R10c)2, —N(R10c)C(O)OR10c, —C(O)OR10c, —OC(O)R10c, —S(O)R10c, —S(O)2R10c, —NO2, ═O, ═S, ═N(R10c), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9c;
• or
• RZ together with RC form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c;
• R5 is selected from:
• hydrogen;
• halogen, —OR10d, —SR10d, —N(R10d)2, —C(O)R10d, —C(O)N(R10d)2, —N(R10d)C(O)R10d, —C(O)OR10d, —OC(O)R10d, —N(R10d)C(O)N(R10d)2, —OC(O)N(R10d)2, —N(R10d)C(O)OR10d, —S(O)R10d, —S(O)2R10d, —NO2, —N3, and —CN;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10d, —SR10d, N(R10d)2, —C(O)R10d, —C(O)N(R10d)2, —N(R10d)C(O)R10d, —C(O)OR10d, —OC(O)R10d, —N(R10d)C(O)N(R10d)2, —OC(O)N(R10d)2, —N(R10d)C(O)OR10d, —S(O)R10d, —S(O)2R10d, —NO2, -O, ═S, ═N(R10d), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9d;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10d, —SR10d, —N(R10d)2, —C(O)R10d, —C(O)N(R10d)2, —N(R10d)C(O)R10d, —N(R10d)C(O)N(R10d)2, —OC(O)N(R10d)2, —N(R10d)C(O)OR10d, —C(O)OR10d, —OC(O)R10d, —S(O)R10d, —S(O)2R10d, —NO2, ═O, ═S, ═N(R10d), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9d;
• or
• R5 together with R6 form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9d;
• R6 is selected from:
• hydrogen;
• halogen, —OR10e, —SR10e, —N(R10e)2, —C(O)R10e, —C(O)N(R10e)2, —N(R10e)C(O)R10e, —C(O)OR10e, —OC(O)R10e, —N(R10e)C(O)N(R10e)2, —OC(O)N(R10e)2, —N(R10e)C(O)OR10e, —S(O)R10e, —S(O)2R10e, —NO2, —N3, and —CN;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10e, —SR10e, —N(R10e)2, —C(O)R10e, —C(O)N(R10e)2, —N(R10e)C(O)R10e, —C(O)OR10e, —OC(O)R10e, —N(R10e)C(O)N(R10e)2, —OC(O)N(R10e)2, —N(R10e)C(O)OR10e, —S(O)R10e, —S(O)2R10e, —NO2, -O, ═S, ═N(R10e), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9e;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10e, —SR10e, —N(R10e)2, —C(O)R10e, —C(O)N(R10e)2, —N(R10e)C(O)R10e, —N(R10e)C(O)N(R10e)2, —OC(O)N(R10e)2, —N(R10e)C(O)OR10e, —C(O)OR10e, —OC(O)R10e, —S(O)R10e, —S(O)2R10e, —NO2, ═O, ═S, ═N(R10e), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9e;
• or
• R6 together with R5 form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9e;
• R7 is selected from:
• hydrogen;
• C(O)R10f, —C(O)N(R10f)2, —C(O)OR10f, —S(O)R10f, and —S(O)2R10f, C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10f, —SR10f, —N(R10f)2, —C(O)R10f, —C(O)N(R10f)2, —N(R10f)C(O)R10f, —C(O)OR10f, —OC(O)R10f, —N(R10f)C(O)N(R10f)2, —OC(O)N(R10f)2, —N(R10f)C(O)OR10f, —S(O)R10f, —S(O)2R10f, —NO2, ═O, ═S, ═N(R10f), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9f;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10f, —SR10f, —N(R10f)2, —C(O)R10f, —C(O)N(R10f)2, —N(R10f)C(O)R10f, —N(R10f)C(O)N(R10f)2, —OC(O)N(R10f)2, —N(R10f)C(O)OR10f, —C(O)OR10f, —OC(O)R10f, —S(O)R10f, —S(O)2R10f, —NO2, ═O, ═S, —N(R10f), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9f;
• R8 is selected from:
• hydrogen;
• C(O)R10g, —C(O)N(R10g)2, —C(O)OR10g, —S(O)R10g, and —S(O)2R10g;
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —C(O)OR10g, —OC(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —S(O)R10g, —S(O)2R10g, —NO2, ═O, ═S, ═N(R10g), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9g;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —C(O)OR10g, —OC(O)R10g, —S(O)R10g, —S(O)2R10g, —NO2, ═O, ═S, ═N(R10g), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more substituents independently selected from R9g;
• each R9a is independently selected from:
• halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, —S(O)2R10a, —NO2, -O, ═S, ═N(R10a), —N3, and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10a, —SR10a, —N(R10a)2, —C(O)R10a, —C(O)N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)N(R10a)2, —OC(O)N(R10a)2, —N(R10a)C(O)OR10a, —C(O)OR10a, —OC(O)R10a, —S(O)R10a, —S(O)2R10a, —NO2, ═O, ═S, ═N(R10a), —N3, and —CN;
• R9bB, R9bD, and R9bE are each independently selected from:
• hydrogen;
• halogen, —NO2, —N3, —CN, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, and —S(O)2R10b;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —C(O)OR10b, —OC(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, =N(R10b), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
• R9bC is selected from:
• halogen, —NO2, —N3, —CN, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, —C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, C(O)OR10b, —OC(O)R10b, —S(O)R10b, and —S(O)2R10b;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, C(O)N(R10b)2, —N(R10b)C(O)R10b, C(O)OR10b, —OC(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —S(O)R10b, —S(O)2R10b, —NO2, ═O, ═S, ═N(R10b), —N3, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10b, —SR10b, —N(R10b)2, —C(O)R10b, C(O)N(R10b)2, —N(R10b)C(O)R10b, —N(R10b)C(O)N(R10b)2, —OC(O)N(R10b)2, —N(R10b)C(O)OR10b, —C(O)OR10b, —OC(O)R10b, —S(O)R10b, —S(O)2R10b, —NO2, —O, ═S, ═N(R10b), —N3, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
• each R9z is independently selected from:
• halogen, —OR10z, —SR10z, —N(R10z)2, —C(O)R10z, —C(O)N(R10z)2, —N(R10z)C(O)R10z, —N(R10z)C(O)N(R10z)2, —OC(O)N(R10z)2, —N(R10z)C(O)OR10z, —C(O)OR10z, —OC(O)R10z, —S(O)R10z, —S(O)2R10z, —NO2, ═O, ═S, ═N(R10z), —N3, and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10z, —SR10z, —N(R10z)2, —C(O)R10z, —C(O)N(R10z)2, —N(R10z)C(O)R10z, —N(R10z)C(O)N(R10z)2, —OC(O)N(R10z)2, —N(R10z)C(O)OR10z, —C(O)OR10z, —OC(O)R10z, —S(O)R10z, —S(O)2R10z, —NO2, ═O, ═S, ═N(R10z), —N3, and —CN;
• each R9c is independently selected from:
• halogen, —OR10c, —SR10c, —N(R10c)2, —C(O)R10c, —C(O)N(R10c)2, —N(R10c)C(O)R10c, —N(R10c)C(O)N(R10c)2, —OC(O)N(R10c)2, —N(R10c)C(O)OR10c, —C(O)OR10c, —OC(O)R10c, —S(O)R10c, —S(O)2R10c, —NO2, ═O, ═S, ═N(R10c), —N3, and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10c, —SR10c, —N(R10c)2, —C(O)R10c, —C(O)N(R10c)2, —N(R10c)C(O)R10c, —N(R10c)C(O)N(R10c)2, —OC(O)N(R10c)2, —N(R10c)C(O)OR10c, —C(O)OR10c, —OC(O)R10c, —S(O)R10c, —S(O)2R10c, —NO2, ═O, ═S, ═N(R10c), —N3, and —CN;
• each R9d is independently selected from:
• halogen, —OR10d, —SR10d, —N(R10d)2, —C(O)R10d, —C(O)N(R10d)2, —N(R10d)C(O)R10d, —N(R10d)C(O)N(R10d)2, —OC(O)N(R10d)2, —N(R10d)C(O)OR10d, —C(O)OR10d, —OC(O)R10d, —S(O)R10d, —S(O)2R10d, —NO2, ═O, ═S, ═N(R10d), —N3, and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10d, —SR10d, —N(R10d)2, —C(O)R10d, —C(O)N(R10d)2, —N(R10d)C(O)R10d, —N(R10d)C(O)N(R10d)2, —OC(O)N(R10d)2, —N(R10d)C(O)OR10d, —C(O)OR10d, —OC(O)R10d, —S(O)R10d, —S(O)2R10d, —NO2, ═O, ═S, ═N(R10d), —N3, and —CN;
• each R9e is independently selected from:
• halogen, —OR10e, —SR10e, —N(R10e)2, —C(O)R10e, —C(O)N(R10e)2, —N(R10e)C(O)R10e, —N(R10e)C(O)N(R10e)2, —OC(O)N(R10e)2, —N(R10e)C(O)OR10e, —C(O)OR10e, —OC(O)R10e, —S(O)R10e, —S(O)2R10e, —NO2, ═O, ═S, ═N(R10e), —N3, and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10e, —SR10e, —N(R10e)2, —C(O)R10e, —C(O)N(R10e)2, —N(R10e)C(O)R10e, —N(R10e)C(O)N(R10e)2, —OC(O)N(R10e)2, —N(R10e)C(O)OR10e, —C(O)OR10e, —OC(O)R10e, —S(O)R10e, —S(O)2R10e, —NO2, ═O, ═S, ═N(R10e), —N3, and —CN;
• each R9f is independently selected from:
• halogen, —OR10f, —SR10f, —N(R10f)2, —C(O)R10f, —C(O)N(R10f)2, —N(R10f)C(O)R10f, —N(R10f)C(O)N(R10f)2, —OC(O)N(R10f)2, —N(R10f)C(O)OR10f, —C(O)OR10f, —OC(O)R10f, —S(O)R10f, —S(O)2R10f, —NO2, ═O, ═S, ═N(R10f), —N3, and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10f, —SR10f, —N(R10f)2, —C(O)R10f, —C(O)N(R10f)2, —N(R10f)C(O)R10f, —N(R10f)C(O)N(R10f)2, —OC(O)N(R10f)2, —N(R10f)C(O)OR10f, —C(O)OR10f, —OC(O)R10f, —S(O)R10f, —S(O)2R10f, —NO2, ═O, ═S, ═N(R10f), —N3, and —CN;
• each R9g is independently selected from:
• halogen, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —C(O)OR10g, —OC(O)R10g, —S(O)R10g, —S(O)2R10g, —NO2, ═O, ═S, ═N(R10g), —N3, and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10g, —SR10g, —N(R10g)2, —C(O)R10g, —C(O)N(R10g)2, —N(R10g)C(O)R10g, —N(R10g)C(O)N(R10g)2, —OC(O)N(R10g)2, —N(R10g)C(O)OR10g, —C(O)OR10g, —OC(O)R10g, —S(O)R10g, —S(O)2R10g, —NO2, ═O, ═S, ═N(R10g), —N3, and —CN;
• and
• each R10a, R10b, R10z, R10c, R10d, R10e, R10f, and R10g is independently selected from:
• hydrogen;
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, =O, =S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.