Benzenesulfonamide derivatives and uses thereof

A compound represented by the structure:

• wherein:
• G1 is a protein binder;
• R1 is —CN, —OR3, —SR3, —S(═O)R3, —S(═O)2R3, —S(═O)(═NR3)R3, —S(═O)2N(R3)2, —OS(═O)2R3, —N(R3)2, —NR3C(═O)R3, —NR3C(═O)N(R3)2, —NR3C(═NR3)N(R3)2, —C(═O)R3, —OC(═O)R3, —C(═O)OR3, —OC(═O)OR3, —OC(═O)N(R3)2, —NR3C(═O)OR3, —C(═O)N(R3)2, NO2, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 haloalkyl, substituted or unsubstituted C1-C6 heteroalkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C5 alkynyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C2-C7 heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —CN, —OR3, —SR3, —S(═O)R3, —S(═O)2R3, —S(═O)2N(R3)2, —N(R3)2, —C(═O)R3, —OC(═O)R3, —C(═O)OR3, —OC(═O)N(R3)2, —NR3C(═O)OR3, or —C(═O)N(R3)2;
• each R3 is independently hydrogen, —C(═O)(C2-C6 alkenyl), —C(═O)(C2-C6 alkynyl), substituted or unsubstituted C1-C4 alkyl, —(C1-C4 alkylene)-R4, substituted or unsubstituted C1-C4 haloalkyl, substituted or unsubstituted C1-C4 heteroalkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C5 alkynyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C2-C7 heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or two R3 on the same nitrogen atom are joined together to form substituted or unsubstituted C2-C7 heterocycloalkyl;
• and
• R4 is substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C2-C7 heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl,
• or a salt or solvate thereof.