Aromatic ring or heteroaromatic ring derivatives, preparation method therefor and use thereof

A compound represented by general formula (I):

• wherein W, Y and Z are each independently selected from CRn and N, and there are at most 2 N atoms contained among W, Y, and Z;
• R1 is selected from —COORa and tetrazolyl;
• R2 is selected from 8- to 10-membered heteroaryl and —NRbRc, wherein the heteroaryl is optionally further substituted with one or more substituents selected from Rd;
• R3 is selected from —NReRf and the group
• Y1, Y2, Y3 and Y4 are each independently selected from CRj and N, and there are at most 3 N atoms contained among Y1, Y2, Y3 and Y4;
• ring A is selected from 6- to 8-membered monocyclic heterocyclyl and 5-membered heteroaryl, wherein the monocyclic heterocyclyl contains one or more N, O or S(O)n therein, and the 6- to 8-membered heterocycle is optionally further substituted by one or more R10;
• Ra is selected from hydrogen atom and alkyl, wherein the alkyl is optionally further substituted with one or more halogens;
• Rb is the group:
• Rc is alkyl;
• Re is selected from hydrogen atom and alkyl, wherein the alkyl is optionally further substituted with one or more substituents selected from hydroxyl, alkoxy and halogen;
• Rf is selected from -L-Rk,
• L is selected from C1-6 alkylene;
• wherein the C1-6 alkylene is substituted or unsubstituted, when the C1-6 alkylene is substituted, the C1-6 alkylene is substituted by one or more groups selected from the following:
• alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylamino, halogen, mercapto, hydroxyl, nitro, cyano, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkoxy, heterocycloalkoxy, cycloalkylthio, heterocycloalkylthio, amino, haloalkyl, hydroxyalkyl, carboxyl, carboxylic ester groups, —C(O)R4, —C(O)OR4, —OC(O)R4, —NR5R6, —C(O)NR5R6, —SO2NR5R6 and —NR5C(O)R6;
• Rg and Rh are each independently selected from hydrogen atom, alkyl, alkoxy, halogen and cyano, wherein the alkyl or alkoxy is optionally further substituted with one or more halogen or alkoxy;
• Rk is selected from aryl and heteroaryl, wherein the aryl or heteroaryl is optionally further substituted with one or more Rm;
• Rd, Rj, Rm, Rn and R10 are the same or different, and are each independently selected from hydrogen atom, hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(O)R4, —C(O)OR4, —OC(O)R4, —NR5R6, —C(O)NR5R6, —S(O)nNR5R6 and —NR5C(O)R6, wherein the alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted with one or more substituents selected from hydroxyl, halogen, nitro, cyano, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, ═O, —C(O)R4, —C(O)OR4, —OC(O)R4, —NR5R6, —C(O)NR5R6, —SO2NR5R6 and —NR5C(O)R6;
• R4, R5 and R6 are each independently selected from hydrogen atom, hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted with one or more substituents selected from hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(O)R7, —C(O)OR7, —OC(O)R7, —NR8R9, —C(O)NR8R9, —SO2NR8R9 and —NR8C(O)R9;
• or, R5 and R6, together with the N atom connected thereto, form a 4- to 8-membered heterocyclyl, wherein the 4- to 8-membered heterocycle contains one or more N, O or S(O)n, and the 4- to 8-membered heterocycle is optionally further substituted with one or more substituents selected from hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, ═O, —C(O)R7, —C(O)OR7, —OC(O)R7, —NR8R9, —C(O)NR8R9, —SO2NR8R9 and —NR8C(O)R9;
• R7, R8 and R9 are each independently selected from hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted with one or more substituents selected from hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl and carboxylic ester groups;
• m is selected from 0, 1, 2, 3, 4 and 5;
• n is selected from 0, 1 and 2;
• and
• q is 0, 1, 2, 3, 4 or 5;
• a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof.