# US 12,558,536 B2 · Systems and methods for therapeutic nasal treatment

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- Number: US 12,558,536 B2
- Document ID: US12558536B2
- Status: Granted
- Kind: B2
- Application number: 18/438,989
- Filed: 2024-02-12
- Published: 2024-06-06
- Granted: 2026-02-24
- Earliest claimed: 2020-04-09
- Assignees: Neurent Medical Limited
- Applicants: Neurent Medical Limited
- Inventors: David Townley
- Web page: https://patentgrep.com/patent/US12558536B2

## CPC

- A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)}
- A61N 1/0546: {Nasal electrodes}
- A61B 18/02: by cooling, e.g. cryogenic techniques
- A61B 18/082: {Probes or electrodes therefor}
- A61B 18/1485: {having a short rigid shaft for accessing the inner body through natural openings}
- A61N 1/3606: {adapted for a particular treatment}
- A61B 2018/00267: {having a basket shaped structure}
- A61B 2018/00327: {Ear, nose or throat}
- A61B 2018/00404: {Blood vessels other than those in or around the heart}
- A61B 2018/00434: {Neural system}
- A61B 2018/00577: {Ablation}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

The invention provides a device for treating at least one of rhinitis, congestion, and/or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes a shaft, a retractable and expandable end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The shaft includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the end effector.

## Claims

### Claim 1

A device for treating a condition within a sino-nasal cavity of a patient, the device comprising:
a shaft comprising:
an outer sheath comprising an encapsulated braid along a length thereof and further comprising an inner lining including a low friction polytetrafluoroethylene (PTFE) material; and
a hypotube surrounded by the outer sheath,
wherein the hypotube comprises an array of a first set of electrodes provided along a portion thereof, and wherein the outer sheath comprises a plurality exposed portions associated with each of the first set of electrodes thereby revealing the first set of electrodes; and
a retractable and expandable end effector operably associated with the shaft and comprising an array of a second set of electrodes provided thereon, wherein the second set of electrodes of the retractable and expandable end effector are configured to operate independently of the first set of electrodes of the hypotube.

### Claim 2 (depends on 1)

The device of claim 1, wherein the shaft comprises one or more of a plurality of support elements forming at least a portion of the end effector.

### Claim 3 (depends on 1)

The device of claim 1, wherein each of the first set of electrodes is positioned on separate respective portion of the hypotube.

### Claim 4 (depends on 1)

The device of claim 1, wherein each electrode of the array of the first set of electrodes is configured to deliver energy to a first target site associated with an inferior or middle turbinate within a nasal cavity of a patient to reduce engorgement of tissue associated with the inferior turbinate to thereby increase volumetric flow through a nasal passage of the patient.

### Claim 5 (depends on 1)

The device of claim 1, wherein the end effector is a multi-segment end effector that comprises a first retractable and expandable segment that is spaced apart from a separate second retractable and expandable segment, wherein each of the first and second segments comprises respective arrays of second and third sets of electrodes provided thereon and configured to operate independently of at least the array of the first set of electrodes.

### Claim 6 (depends on 5)

The device of claim 5, wherein:
the first segment comprises a first set of flexible support elements arranged in a deployed configuration to fit around at least a portion of a middle turbinate at an anterior position relative to posterior-inferior edge of the middle turbinate; and
the second segment comprises a second set of flexible support elements configured in a deployed configuration to contact a plurality of tissue locations in a cavity at a posterior position relative to the posterior-inferior edge of the middle turbinate.

### Claim 7 (depends on 6)

The device of claim 6, wherein each electrode of the arrays of the second and third sets of electrodes is configured to deliver energy to a second target site associated with a sphenopalatine foramen within the nasal cavity of the patient to therapeutically modulate postganglionic parasympathetic nerves innervating nasal mucosa at microforamina of a palatine bone of the patient.