Targeted in situ therapeutic delivery of secreted factors from stem cells for treatment of damaged tissue
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States Government AS Represented By the Department of Veteran Affairs, The Board of Trustees of the University of Illinois
InventorsDavid Myung, Gabriella Fernandes-Cunha, Hyun Jong Lee, Ali Djalilian
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Abstract
Compositions and methods for repairing or regenerating damaged tissue are disclosed. In particular, the invention relates to methods of delivering secreted factors from stem cells to tissues in order to immobilize and concentrate such secreted factors at or under the surface of damaged tissue to promote tissue regeneration.
Claims11
A method of accelerating wound healing and reducing neovascularization and scar formation, in damaged tissue in a subject, the method comprising:
- a) collecting a bone marrow-derived mesenchymal stem cell (MSC) secretome from a mesenchymal stem cell;
- b) mixing the bone marrow-derived mesenchymal stem cell (MSC) secretome from the stem cell with a solution comprising at least one biocompatible polymer or biopolymer to form a mixture;
- wherein said at least one biocompatible polymer or biopolymer comprises a mixture of hyaluronic acid and chondroitin sulfate;
- and
- c) applying the mixture to the damaged tissue, wherein the bone marrow-derived mesenchymal stem cell (MSC) secretome from the stem cell accelerates healing at or under the surface of the damaged tissue;
- wherein the damaged tissue is ocular tissue, wherein the ocular tissue is corneal or stromal tissue;
- and wherein the bone marrow-derived MSC secretome reduces neovascularization and scar formation in the damaged tissue.
Dependencies are inferred from the claim text.