Graded porous scaffolds as immunomodulatory wound patches
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsAzadeh Timnak, Peter I. Lelkes, Yah-el H. Har-el
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Abstract
The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.
Claims20
A scaffold comprising:
- a porous material comprising plant protein fibers having a first surface, a second surface, and a thickness therebetween;
- wherein the average pore size at the first surface is smaller than the average pore size at the second surface;
- wherein the average pore size gradually increases through the material from the first surface to the second surface, and
- wherein the second surface is configured to allow the passage of cells into the thickness of the material, and the first surface is configured to prohibit the passage of cells into or out of the thickness of the material.
A scaffold comprising a porous material comprising plant protein fibers having a first surface, an opposing second surface, and a thickness therebetween, wherein the average pore size of the material gradually increases through the material thickness from the first surface to the second surface, wherein the first surface is configured to prohibit the passage of cells, and wherein the second surface is configured to allow cell penetration into the thickness of the material up to the first surface.
Dependencies are inferred from the claim text.